With the rising technological improvements in medical therapies, cell-based therapies maintain nice potential as environment friendly instruments towards varied beforehand incurable illnesses by restoring or altering the perform of sure units of cells. Alongside this line, a necessary issue to find out the success of cell remedy is the selection of cell supply technique. Lately, a novel pattern is blooming within the utility of microneedles system, which relies on the miniaturization of a number of needles inside a patch to the micrometer dimensions, aimed on the supply of therapeutic cells to the goal web site with excessive effectivity and minimally invasive. This evaluation goals to show the benefits of exploiting microneedles-based know-how as a brand new device for cell remedy. The developments of microneedles-based methods for cell supply are summarized by way of two classes: cell-free and cell-loaded microneedles programs. And majority researches of microneedles-based cell remedy have proven promising outcomes for tissue regeneration, most cancers immunotherapy, pores and skin immune monitoring and focused cell supply. Lastly, present challenges and future views towards the event and utility of microneedles for cell remedy are additionally mentioned.